Simultaneous estimation of Naproxen and Curcumin in combined dosage form using UV spectroscopy
K. Lokesh
, G. Skanda Saved , P Sridevi
Keywords: Naproxen, Curcumin, UV spectrophotometry, antioxidant, anti-inflammatory, simultaneous estimation, method validation.
ABSTRACT:
Aim: This research article presents the development and validation of an analytical method for the simultaneous determination of Naproxen and Curcumin in a combined tablet dosage form.
Materials and Methods: The method employs the simultaneous equation approach, relying on absorbance readings at 232nm and 424nm, which correspond to the maximum absorbance wavelengths of Naproxen and Curcumin, respectively.
The validation of the method followed ICH Q2(R1) guidelines, assessing parameters such as linearity, accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ).
Results: Calibration curves demonstrated linearity within the concentration range of 1–3 µg/mL for Naproxen and 1–10 µg/mL for Curcumin, with correlation coefficients of 0.9924 and 0.999, respectively.
The method was validated in accordance with ICH Q2(R1) for the aforementioned parameters. Recovery experiments indicated high accuracy, with percentage recoveries between 99.2% and 100.8% for Naproxen and 99.8% to 100.1% for Curcumin. The LOD values were determined to be 0.096 µg/mL and 0.311 µg/mL, while the LOQ values were 0.29 µg/mL and 0.943 µg/mL for Naproxen and Curcumin, respectively.
Conclusion: The proposed method was effectively utilized for the analysis of the tablet dosage form and was found to be dependable, sensitive, and appropriate for regular quality control purposes.
"Simultaneous estimation of Naproxen and Curcumin in combined dosage form using UV spectroscopy ", JETNR - JOURNAL OF EMERGING TRENDS AND NOVEL RESEARCH (www.JETNR.org), ISSN:2984-9276, Vol.4, Issue 6, page no.c1-c7, June-2026, Available :https://rjpn.org/JETNR/papers/JETNR2606226.pdf
Volume 4
Issue 6,
June-2026
Pages : c1-c7
Paper Reg. ID: JETNR_235278
Published Paper Id: JETNR2606226
Downloads: 00040
Research Area: Pharmacy All
Country: Rangareddy, Telangana, India
ISSN: 2984-9276 | IMPACT FACTOR: 9.87 Calculated By Google Scholar | ESTD YEAR: 2023
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.87 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: RJPN (IJPublication) Janvi Wave
