A systematic review on: mesoporous silica as an excipient
Shruti Shirsath
, Dr, santosh surana
Mesoporous silica nanoparticles (MSNs), Tablet formulation, Direct compression, Drug loading, Solvent-based methods, Solvent-free methods
Mesoporous silica nanoparticles (MSNs) have emerged as promising multifunctional excipients in pharmaceutical formulations, particularly in tablet drug delivery systems. Tablets remain the most preferred dosage form due to their cost-effectiveness and ease of manufacturing; however, limitations in compressibility and compactability restrict the widespread application of direct compression techniques. Mesoporous silica materials, characterized by pore sizes between 2–50 nm, offer unique advantages such as high surface area, tunable pore structure, biocompatibility, and chemical stability. These properties contribute to improved powder flow, enhanced compactability, and better tablet performance. Nanosized colloidal silica further aids in reducing interparticle friction and electrostatic interactions, thereby improving processability and uniformity. Additionally, MSNs play a crucial role in enhancing drug loading and release characteristics. Both solvent-based methods (adsorption, incipient wetness impregnation, solvent evaporation, and one-pot synthesis) and solvent-free techniques (melt method, microwave irradiation, microwave-assisted synthesis, and co-milling) have been extensively explored for efficient drug incorporation into mesoporous structures. The choice of method significantly influences drug loading efficiency, physical state, and release kinetics. Furthermore, the concentration of mesoporous silica critically affects tablet properties, including flow behavior, compressibility, and disintegration. Overall, mesoporous silica-based systems offer a versatile and effective approach to overcome formulation challenges, making them highly suitable for advanced drug delivery applications.
"A systematic review on: mesoporous silica as an excipient ", JETNR - JOURNAL OF EMERGING TRENDS AND NOVEL RESEARCH (www.JETNR.org), ISSN:2984-9276, Vol.4, Issue 6, page no.a23-a25, June-2026, Available :https://rjpn.org/JETNR/papers/JETNR2606005.pdf
Volume 4
Issue 6,
June-2026
Pages : a23-a25
Paper Reg. ID: JETNR_234713
Published Paper Id: JETNR2606005
Downloads: 00083
Research Area: Pharmacy All
Country: Kalwan, Maharashtra, India
ISSN: 2984-9276 | IMPACT FACTOR: 9.87 Calculated By Google Scholar | ESTD YEAR: 2023
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.87 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: RJPN (IJPublication) Janvi Wave
