COMPARATIVE REVIEW OF MECHANISMS, EFFICACY, AND SAFETY OF HERBAL AND SYNTHETIC ANALGESICS AND ANTIPYRETICS
Aman kumar
, Ashish kumar , Mrs. Hurmandeep kaur , Mr. Rajat koundal , Shubham garg
Analgesics, Antipyretics, Herbal Drugs, Synthetic Drugs, Safety, Efficacy
Pain and fever are typical clinical disorders that need the effective use of analgesic and antipyretic substances. This is a comparative review of the herbal and synthetic drugs in relation to their mechanisms of action, efficacy, and safety profiles. NSAIDs and paracetamol are synthetic drugs whose initial mechanism of action is via inhibition of the enzymes called cyclooxygenase and synthesis of proteins known as prostaglandins with quick and predictable therapeutic responses. Conversely, the anti-inflammatory, antioxidant, and immunomodulatory pathways are multi-targets of the herbal drugs such as turmeric, ginger, and willow bark. The comparative analysis suggests that synthetic drugs are very effective in acute conditions, as they take effect quickly, and the dosage is standard, but they have adverse effects like gastrointestinal, hepatic, and cardiovascular toxicity. Although herbal drugs are slower acting, less effective when the disease is severe, they are both more tolerable and more appropriate when used long-term. The lack of standardization and variability in composition is one of the major shortcomings of herbal therapies. On the whole, the integrative approach that involves the combination of systems with evidence-based practice could improve the outcomes of therapeutic processes and reduce risks. Standardization, nanotechnology, and personalized medicine are all areas that are likely to enhance safety and efficacy, as well as international acceptance of these therapies.
"COMPARATIVE REVIEW OF MECHANISMS, EFFICACY, AND SAFETY OF HERBAL AND SYNTHETIC ANALGESICS AND ANTIPYRETICS", JETNR - JOURNAL OF EMERGING TRENDS AND NOVEL RESEARCH (www.JETNR.org), ISSN:2984-9276, Vol.4, Issue 4, page no.d139-d157, April-2026, Available :https://rjpn.org/JETNR/papers/JETNR2604413.pdf
Volume 4
Issue 4,
April-2026
Pages : d139-d157
Paper Reg. ID: JETNR_234176
Published Paper Id: JETNR2604413
Downloads: 00025
Research Area: Pharmacy All
Country: fatehgarh Sahib, Punjab, India
ISSN: 2984-9276 | IMPACT FACTOR: 9.87 Calculated By Google Scholar | ESTD YEAR: 2023
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.87 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: RJPN (IJPublication) Janvi Wave
