Eco-Friendly Synthesis of Aspirin Nanoparticles using Plant Extracts for Enhanced Solubility and Bioavailability
Dr. Rishabh Bhardwaj
, Dr. Rahul Arya
Aspirin nanoparticles,Green synthesis,Plant extract-mediated synthesis,Phytochemicals Nano pharmaceuticals,Drug solubility enhancement,Bioavailability improvement,Sustainable chemistry
Aspirin (acetylsalicylic acid) is a widely used therapeutic agent; however, its clinical effectiveness is often limited by poor aqueous solubility and moderate bioavailability. The present study reports an eco-friendly and sustainable approach for the synthesis of aspirin nanoparticles using plant extracts as natural reducing, capping, and stabilizing agents. The synthesis was carried out via a modified esterification process involving salicylic acid and acetic anhydride in the presence of phytochemical-rich plant extracts under controlled conditions of temperature and pH. Bioactive compounds such as flavonoids, phenolics, and tannins play a crucial role in regulating nucleation, minimizing particle size, and preventing aggregation, thereby enabling the formation of stable nanoparticles.
The synthesized nanoparticles were characterized using UV–Visible spectroscopy, pH measurement, conductivity analysis, viscosity studies, and flame photometry. A hypsochromic shift in the UV–Visible spectrum confirmed the formation of nanoscale aspirin particles. The nanoparticles exhibited improved dispersion behavior, enhanced viscosity, and stable physicochemical properties compared to bulk aspirin. These modifications contribute to increased solubility and are expected to enhance bioavailability.
This study demonstrates that plant-mediated green synthesis is a cost-effective, environmentally benign, and scalable method for producing aspirin nanoparticles with superior pharmaceutical properties. The findings highlight the potential of this approach in advancing sustainable nanopharmaceutical development and improving drug delivery performance.
"Eco-Friendly Synthesis of Aspirin Nanoparticles using Plant Extracts for Enhanced Solubility and Bioavailability", JETNR - JOURNAL OF EMERGING TRENDS AND NOVEL RESEARCH (www.JETNR.org), ISSN:2984-9276, Vol.4, Issue 4, page no.c86-c90, April-2026, Available :https://rjpn.org/JETNR/papers/JETNR2604274.pdf
Volume 4
Issue 4,
April-2026
Pages : c86-c90
Paper Reg. ID: JETNR_233924
Published Paper Id: JETNR2604274
Downloads: 00044
Research Area: Chemistry All
Country: MUZAFFARNAGAR, UTTER PRADESH, India
ISSN: 2984-9276 | IMPACT FACTOR: 9.87 Calculated By Google Scholar | ESTD YEAR: 2023
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.87 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: RJPN (IJPublication) Janvi Wave
