Novel Therapeutic Approaches in Alzheimer's disease
Muskan Mishra
, Abhishek Chaturvedi
Alzheimer’s disease, Neurodegeneration, Amyloid-beta plaques, Tau protein tangles, Monoclonal antibodies, Anti-amyloid therapy, Anti-tau therapy, Neuroinflammation, Microglial activation, Oxidative stress, Neuroprotection, Gene therapy, Stem cell therapy, Nanotechnology drug delivery, Blood-brain barrier,
Alzheimer is a progressive neurodegenerative disease that is slowly progressing into memory, ability to think and behavior. It is among the major causes of dementia in the world and becomes a major challenge to the health care systems and society. these pathological alterations interfere with the communication between brain cells that cause damage to neurons and subsequent brain shrinkage.
Thus, the recent studies have been aimed at the creation of new therapeutic methods which could address the causes of the Alzheimer disease.
These therapies are used to delay the progression of the disease particularly when used early in the disease. Likewise, anti-tau medicines are under manufacture to prevent tau protein aggregation and stabilize the microtubules structures in the neurons. Tau pathology is strongly correlated with the severity of the disease, so future treatment should be focused on targeting tau. The other important strategy is aimed at minimizing neuroinflammation. The chronic inflammation in Alzheimer disease is caused by the overactivation of microglial cells, and this also causes neuron damage
Biotechnology has also come up with new approaches such as gene therapy and stem cell therapy. Gene therapy is expected to alter or control the genes that are linked to the risk of Alzheimer whereas stem cell therapy has the potential to replace the damaged neurons and recover the lost brain functions. It is still being researched but these methods have a promise of being used to find a lasting solution. Moreover, the drug delivery systems using nanotechnology are under investigation as a solution to the problem of the blood-brain barrier. [1]
"Novel Therapeutic Approaches in Alzheimer's disease", JETNR - JOURNAL OF EMERGING TRENDS AND NOVEL RESEARCH (www.JETNR.org), ISSN:2984-9276, Vol.4, Issue 4, page no.a376-a386, April-2026, Available :https://rjpn.org/JETNR/papers/JETNR2604047.pdf
Volume 4
Issue 4,
April-2026
Pages : a376-a386
Paper Reg. ID: JETNR_233592
Published Paper Id: JETNR2604047
Downloads: 00041
Research Area: Pharmacy All
Country: Chittorgarh, Rajsthan, India
ISSN: 2984-9276 | IMPACT FACTOR: 9.87 Calculated By Google Scholar | ESTD YEAR: 2023
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.87 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: RJPN (IJPublication) Janvi Wave
